I dunno man, I'm torn about that.
Part of me thinks, yeah, he finished his story, killed his dad (indirectly) and according to the rules of the island, it's time for him to go.
The other part says, nah, locke can't die, the jacob ghost thing will save him and he'll end up taking over from Ben from leading whoever the fuck those people are.
I dunno, I'm going to go check their forums.